It's a fairly well-accepted narrative that manufacturing in America is all but dead. Over 3 million manufacturing jobs were lost during the Great Recession, and what's left will eventually be outsourced -- or so the thinking goes.
But a closer look at the numbers shows that there are a number of big cities across the United States that are enjoying a healthy revival of manufacturing jobs. Below are the top five, as compiled by Forbes, and why they're doing so well.
5. Troy, Mich.
Source: troymi.gov.�
The auto industry was one of the toughest hit during the Great Recession, with both Chrysler and General Motors (NYSE: GM ) needing massive bailouts from the U.S. government. But from the depths of the Recession, Troy is experiencing a comeback.
Top 5 India Stocks For 2015: Acceleron Pharma Inc (XLRN)
Acceleron Pharma Inc., incorporated on June 13, 2003, is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of protein therapeutics for cancer and rare diseases. The Company�� research focuses on the biology of the Transforming Growth Factor-Beta (TGF-b) protein superfamily, a large and diverse group of molecules that are key regulators in the growth and repair of tissues throughout the human body. By coupling its discovery and development expertise, including its knowledge of the TGF-b superfamily, with its internal protein engineering and manufacturing capabilities, it has built a productive research and development platform that has generated clinical and preclinical protein therapeutic candidates with mechanisms of action.
The Company focuses on discovering and developing protein therapeutics that target a group of approximately 30 secreted proteins, or ligands, that are collectively referred to as the TGF-b superfamily. These ligands bind to subsets of 12 different receptors on the surface of cells, triggering intra-cellular changes in gene expression that guide cell growth and differentiation. The TGF-b superfamily ligands and their receptors represent an under-explored and diverse set of drug targets with the potential to yield therapeutics that modulate the growth and repair of diseased cells and tissues.
The Company has three internally discovered protein therapeutic candidates that are being studied in 12 ongoing Phase 2 clinical trials, focused on cancer and rare diseases. The Company�� two advanced protein therapeutic candidates, sotatercept and ACE-536, promote red blood cell production through a novel mechanism. Together with its collaboration partner, Celgene Corporation, the Company is developing sotatercept and ACE-536 to treat anemia and associated complications in patients with b-thalassemia and myelodysplastic syndromes (MDS). These red blood cell disorders are generally unresponsive to approved dru! gs. The Company�� third clinical stage protein therapeutic candidate, dalantercept, is designed to inhibit blood vessel formation through a mechanism that is distinct from, and potentially synergistic with, the dominant class of cancer drugs that inhibit blood vessel formation, the vascular endothelial growth factor (VEGF) pathway inhibitors. The Company is developing dalantercept primarily for use in combination with these products to produce better outcomes for cancer patients.
The Company and Celgene have conducted six human clinical trials with sotatercept in over 160 healthy volunteers and cancer patients. The Company has conducted one clinical trial with ACE-536 in healthy volunteers. In these studies, both sotatercept and ACE-536 caused a dose-dependent increase in the number of red blood cells. Based on these results, the Company and Celgene have initiated Phase II clinical trials with each of these protein therapeutic candidates in b-thalassemia and MDS. In the ongoing trial of sotatercept in patients with b-thalassemia, the Company has observed encouraging, dose-dependent increases in hemoglobin in a subset of patients at the two lowest dose levels.
Sotatercept is a soluble receptor fusion protein consisting of the extracellular domain of the activin receptor type IIA (ActRIIA) linked to the Fc domain of human IgG1. Sotatercept acts as a protein trap for TGF-b superfamily ligands that signal through the ActRIIA receptor. Sotatercept has increased red blood cells in multiple clinical trials. ACE-536 is a soluble receptor fusion protein consisting of a modified extracellular domain of the activin receptor type IIB (ActRIIB) linked to the Fc domain of human IgG1.
Advisors' Opinion:- [By Jake L'Ecuyer]
Shares of Acceleron Pharma (NASDAQ: XLRN) got a boost, shooting up 16.74 percent to $39.54 after Form 8-K for Acceleron Pharma showed that Celgene (NASDAQ: CELG) will buy 1.1 million shares for $47.15 million.
- [By Ben Levisohn]
3. We see 23+ partnered pipeline assets and are most positive on Phase I/II MOR202 anti-CD38 for myeloma with data in 2015, and others such as Acceleron Pharma (XLRN), Agios Pharmaceuticals (AGIO), Epizyme (EPZM), Concert Pharmaceuticals (CNCE) (just started Phase I for next-gen Revlimid).
- [By John Udovich]
The biotech sector has been pretty exciting this year�with small cap biotech stocks Prana Biotechnology Limited (NASDAQ: PRAN) and TNI BioTech (OTCMKTS: TNIB) having recently produced noteworthy news for investors�while Acceleron Pharma, Inc (NASDAQ: XLRN), Ophthotech (NASDAQ: OPHT) and BIND Therapeutics (NASDAQ: BIND) have just�set term sheets for their upcoming IPOs. Just consider all of the following recent news:
5 Best Integrated Utility Stocks To Own Right Now: Asanko Gold Inc (AKG)
Asanko Gold Inc., incorporated on September 23, 1999, is a natural resource company engaged in the acquisition and exploration of mineral resources in West Ghana. Its mineral properties are in the exploration and development stage. Its primary property is the Esaase project. The Company is focused on advancing the Esaase Gold Project to commercial production. In addition to its principal project, the Company holds a portfolio of other Ghanaian gold concessions in various stages of exploration. As of February 28, 2014, the Company�� material properties consisted of the Asanko Gold Mine project, the Asumura Property and the Diaso Property, all in West Ghana, Africa. In February 2014, Asanko Gold Inc successfully completed the acquisition of PMI Gold Corporation.
Asanko Gold Mine Property
The Asanko Gold Mine Property is a development stage property located in the Amansi East District of Ghana, approximately 35 kilometers south west of the regional capital Kumasi. The property comprises the Nkran pit, the Adubiaso pit, the Dynamite Hill deposit, the Asuadai deposit, the Abore pit and the Esaase deposit. The Property has gold resources of approximately 7.52 million ounces and gold reserves of approximately 4.81 million ounces.
The Asumura Property
The Asumura Property is without known resources or reserves and the work being done by the Company is exploratory in nature. The Asumura Property is located in the south-western part of Ghana and is divided into two parts by the Bia River. The western part of the property is within the Western Region of Ghana in the Juabeso Bia District and the eastern part is in the Brong Ahafo Region of Ghana. The Asumura Property consists of two exploration concessions: Fosukrom and Asumura, which together equal 279.4 square kilometers.
Advisors' Opinion:- [By MONEYMORNING]
As well, Primero Mining (NYSE: PPP) bought Brigus Gold Corp (USA)(NYSE: BRD) for $220 million, and Asanko Gold (NYSEMKT: AKG) is acquiring PMI Gold Corporation (TSE: PMV).
5 Best Integrated Utility Stocks To Own Right Now: Meru Networks Inc.(MERU)
Meru Networks, Inc., together with its subsidiaries, provides wireless local area network (LAN) solutions in the Americas, Europe, the Middle East, Africa, and the Asia Pacific. It offers a virtualized wireless LAN solution based on its System Director Operating System, which runs on its controllers and access points to enable enterprises to deliver business-critical applications over wireless networks. The company?s System Director Operating System provides centralized coordination and control of various access points on the network; controllers synchronize access points to optimize the user experience and manage traffic on the network; and Wi-Fi certified access points to provide network connectivity for wireless devices. It also offers Meru Networks E(z)RF application suite comprising E(z)RF Network Manager, E(z)RF Service Assurance Manager, E(z)RF Location Manager, E(z)RF OnTheGo, Spectrum Manager, and wired and wireless management solutions, which enable enterprises to configure, monitor, troubleshoot, secure, and operate virtualized wireless LAN solution. In addition, the company provides Identity Manager that simplifies enterprise network access and identity management; Wireless Intrusion Prevention System to recognize and mitigate threats; Compliance Manager to reduce the risk of security breach by protecting customer and employee personal information by extending security to the wireless network; AirFirewall to intercept and block unwanted communications as they transmit over the air, stopping them before they reach the network; and Security Gateway SG1000 to meet the demands of the Federal Information Processing Standard, 140-2 Level 3 security required by federal government agencies and other security-conscious organizations. It serves the education, healthcare, hospitality, manufacturing, retail, technology, finance, government, telecom, transportation, and utility markets. The company was founded in 2002 and is headquartered in Sunnyvale, California.
Advisors' Opinion:- [By Eric Volkman]
Meru Networks (NASDAQ: MERU ) isn't wasting any time in finding a successor to one of its top executives. The company announced Monday it had appointed Brian McDonald to be its new CFO to replace the resigning Brett White. McDonald took up his position today, although White will remain at the firm through July 1 in order "to effect a smooth transition."
5 Best Integrated Utility Stocks To Own Right Now: Applied Micro Circuits Corporation(AMCC)
Applied Micro Circuits Corporation, a semiconductor company, together with its subsidiaries, designs, develops, markets, sells, and supports integrated circuits for processing, transporting, and storing information. It offers physical layer products, which transmit and receive signals in a high-speed serial format, and convert high-speed serial formats to low-speed parallel formats and vice versa; framer and mapper products that transmit and receive signals to and from the physical layer in a parallel format are used in high-speed optical network infrastructure equipment; and embedded processor products for wireless infrastructure, wireless LAN, residential, datacenters, and enterprises. The company also offers packet processor ICs, which receive and transmit signals to and from the framing layer and perform the processing of packet and cell headers; and cell switching products that include packet routing switch fabric devices and queuing managers; and printed circuit boar d assemblies to OEMs. Its products are used in wireline and wireless communications equipment, such as wireless access points, wireless base stations, multi-function printers, enterprise and edge switches, blade servers, storage systems, gateways, core switches, routers, network attached storage, and transport platforms. The company offers its solutions for the enterprise, telecom, and consumer/small medium business markets primarily in the United States, Taiwan, Hong Kong, China, Europe, and other Asian countries. Applied Micro Circuits Corporation was founded in 1979 and is headquartered in Sunnyvale, California.
Advisors' Opinion:- [By Lee Jackson]
Applied Micro Circuits Corp. (NASDAQ: AMCC) also has a high single digit exposure to Cisco Systems. Applied Micro�� product portfolio and continued efforts to provide maximum consumer satisfaction have augmented its market position. The integrated offload engines and advanced PacketPro architecture offer quality service and security and performance to its customers. The consensus price target for the stock stands at $13.
- [By Monica Gerson]
Applied Micro Circuits (NASDAQ: AMCC) named Douglas T. Ahrens as its Vice President and Chief Financial Officer. Applied Micro shares declined 2.40% to close at $12.63 yesterday.
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